Vitamin D dose guidance may not be high enough for heart health

 

  • "Vitamin D is an essential nutrient, and researchers are interested in how it may help in several health areas.
  • One area of interest is how much vitamin D supplementation is required to achieve potential cardiac benefits.
  • An initial analysis in a clinical trial suggests that the current recommended dietary allowance of vitamin D in the United States is too low to achieve optimal vitamin D levels for people with certain cardiac problems.
  • Future research in this area will seek to determine if achieving optimal vitamin D levels can decrease the risk for adverse cardiovascular events."

For more details:

https://www.medicalnewstoday.com/articles/vitamin-d-dose-guidance-may-not-be-high-enough-for-heart-health

And a related blogpost:

https://mysciencehealthmooc.blogspot.com/2023/11/getting-adequate-vitamin-d-in-fall-and.html


"And about Vitamin D toxicity:

In healthy individuals, vitamin D toxicity can result from taking excessive vitamin D supplementation, knowingly or accidentally. Prescription errors without frequent monitoring of vitamin D levels can also result in toxicity. Toxicity resulting from lack of monitoring is frequently seen in patients requiring high doses to treat ailments like osteoporosis, renal osteodystrophy, psoriasis, gastric bypass surgery, celiac, or inflammatory bowel disease.

Fortification of foods or supplements with higher than intended amounts of vitamin D has led to toxicity. In 2015, the FDA announced a voluntary recall of multivitamins by Glades Drugs due to excessive amounts of vitamin D. In 2016, the Danish health authority issued a recall for a supplement that had vitamin D levels 75 times higher than recommended. At least 20 children developed toxicity after taking this supplement.

Vitamin D is present in fish, meat, and dairy products, and the dose is rarely enough to cause toxicity. Patients who are on high doses of Vitamin D and taking inadvertently increased amounts of highly fortified milk are also at increased risk for vitamin D toxicity. It can also result from excessive 1,25(OH)2D production in medical ailments like granulomatous disorders and lymphomas.

Excessive sun exposure does not cause vitamin D toxicity due to the regulation and conversion of Vitamin D to its inactive metabolites.

Although mainly reported in animals, exposure to rodenticides containing cholecalciferol can also lead to vitamin D toxicity.

Epidemiology

From 2000 to 2014, a total of 25,397 cases of vitamin D toxicity were reported. Between 2000 and 2005, the annual mean of vitamin D toxicity cases was 196. However, there was a substantial increase of 1600% in exposures from 2005 to 2011, resulting in a new annual mean of 4535 cases. 

According to the latest report from America's Poison Centers (APC), there were 11,718 cases of vitamin D exposure recorded in the National Poison Data System. More than half of these cases were in children younger than 5 years. The vast majority of cases were from unintentional exposures. The total number of vitamin D toxicity cases was greater than the total number of vitamin (vitamins B, A, C, and E) toxicity cases combined. This illustrates the widespread use of vitamin D supplements."

For more details:

https://www.ncbi.nlm.nih.gov/books/NBK557876/

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